Opentargets MCP Server

A Model Context Protocol (MCP) server that exposes the Open Targets Platform GraphQL API as a set of tools for use with Claude Desktop and other MCP-compatible clients. Its 10 documented tools cover target, info, disease, drug. It runs locally over stdio via the published package.

People connecting this server to Claude, Cursor, VS Code, or another MCP client. The project is written in Python.

VERIFIED ACTIVE

LAST COMMIT 2026-05-15 · ★ 19 · #563 OF 848 MAINTAINED OTHER · VERIFIED 2026-08-25

MIT · Python servers · how we verify → /methodology

01 · Install Opentargets

Claude Code

claude mcp add nickzren-opentargets-mcp -- uvx opentargets-mcp

Claude Desktop / Cursor / VS Code - add to config

{
  "mcpServers": {
    "nickzren-opentargets-mcp": {
      "command": "uvx",
      "args": [
        "opentargets-mcp"
      ]
    }
  }
}

Same JSON for Cursor. For VS Code, rename the top-level key from `mcpServers` to `servers`.

Using another client? Same JSON, different key

Claude Desktop · mcpServers

Cursor · mcpServers

VS Code · servers

Windsurf · mcpServers

Zed · context_servers

Cline · mcpServers

Roo Code · mcpServers

Continue · mcpServers

LibreChat · mcpServers

Gemini CLI · mcpServers

Codex CLI · mcp_servers

Full setup guides: every client.

02 · Evidence

Security posture

What to check before giving this server access to your agent - from the registry, GitHub, and our own probes. We don't score safety; we show what's verifiable.

runs as local process (stdio) - runs on your machine with your user's permissions

license MIT - declared in the repository

pypi package opentargets-mcp - check the name against the project README before installing (PyPI has no namespace ownership)

registry namespace io.github.nickzren is GitHub-verified and matches the repo owner

03 · What Opentargets can do

Prose above is summarized from the project's README and registry record - no invented capabilities.

What you can build

An agent gets 10 documented tools spanning target, info, disease, drug, including get_target_info, get_disease_info, get_drug_info, search_entities.

Capability map

Tools grouped from the project's README - what Opentargets lets an agent do.

Target

4 tools - e.g. Core target identity record (Ensembl IDs, synonyms, genomic coordinates); High-confidence target-disease links with scores; Approved and investigational agents for a target

get_target_info · get_target_associated_diseases · get_target_known_drugs · get_target_disease_evidence

Disease

2 tools - e.g. Disease/EFO summary with therapeutic area context; Prioritised target list for an EFO disease

get_disease_info · get_disease_associated_targets

Drug

2 tools - e.g. ChEMBL-backed drug profile and mechanism data; Multi-hop disease -> target -> drug candidate prioritization

get_drug_info · get_drug_repurposing_candidates

read & search

1 tool - e.g. Unified entity search with synonym handling

search_entities

Graphql

1 tool - e.g. Run one GraphQL query across many variable sets

graphql_batch_query

04 · Who maintains Opentargets

opentargets is maintained by nickzren. It's the only MCP server we track from this author; the repo dates to May 2025.

05 · Facts

repository: github.com/nickzren/opentargets-mcp
website: https://nickzren.github.io/opentargets-mcp/
category: other - ranked #563 of 848 actively-maintained other servers as of 2026-08-25.
registry: io.github.nickzren/opentargets (active, first published 2025-09-16 · 2 versions)
packages: pypi:opentargets-mcp

06 · Opentargets FAQ

Is Opentargets still maintained?

Yes - as of 2026-08-25, its last commit was 2026-05-15. We re-verify nightly.

What can Opentargets do?

An agent gets 10 documented tools spanning target, info, disease, drug, including get_target_info, get_disease_info, get_drug_info, search_entities.

How do I install Opentargets?

Run `uvx opentargets-mcp`. You can also paste the ready-made client config above.

Does Opentargets run locally?

Yes - it's a stdio server: it runs on your machine (via uvx) with your user's permissions. Your data stays local unless the server itself calls external APIs.

07 · Alternatives to Opentargets

Alternatives to Opentargets

Maintained other servers if Opentargets isn't the fit.

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